Omega-3 product formulation

KD Nutra® formulation teams review desired label claims and formulation parameters to recommend liquid formula and softgel format that best matches customer input. Omega-3 EPA and DHA combined concentrations can be customized to target different condition specific health applications.

Additionally, the product form can be delivered in Ethel Ester (EE), Triglyceride (rTG) or Free Fatty Acid (FFA). After customer review and approval, the new product formula is finalized and transferred to manufacturing.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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EFSA Health Claims

Docosahexaenoic acid (DHA)

DHA contributes to maintenance of normal brain function
DHA contributes to the maintenance of normal vision
DHA contributes to the maintenance of normal blood triglyceride levels
Docosahexaenoic acid (DHA) maternal intake contributes to the normal brain development of the foetus and breastfed infants.
Docosahexaenoic acid (DHA) intake contributes to the normal visual development of infants up to 12 months of age.
Docosahexaenoic acid (DHA) maternal intake contributes to the normal development of the eye of the foetus and breastfed infants.

Docosahexaenoic acid and Eicosapentaenoic acid (DHA/EPA)

DHA and EPA contribute to the maintenance of normal blood pressure
DHA and EPA contribute to the maintenance of normal blood triglyceride levels

Eicosapentaenoic acid and docosahexaenoic acid (EPA/DHA)

EPA and DHA contribute to the normal function of the heart

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Clinical Studies for Omega 3 acids

Arthritis and Other Inflammatory Diseases

Omega-3 fatty acids ameliorate vascular inflammation: A rationale for their atheroprotective effects https://pubmed.ncbi.nlm.nih.gov/33812168/
Long-term intake of dietary long-chain n-3 polyunsaturated fatty acids and risk of rheumatoid arthritis: a prospective cohort study of women - PubMed (nih.gov)
Nutrients | Free Full-Text | Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials (mdpi.com)

Immunity

Immunomodulatory Effects of Omega-3 Fatty Acids in Patients with Differentiated Thyroid Cancer Before or After Radioiodine Ablation https://pubmed.ncbi.nlm.nih.gov/35293348/
Improved nutritional support with immune-modulating formula in patients with head and neck and esophageal cancer undergoing radiochemotherapy: A retrospective clinical study https://pubmed.ncbi.nlm.nih.gov/32990604/
Effects of omega-3 PUFA on immune markers in adolescent individuals at ultra-high risk for psychosis - Results of the randomized controlled Vienna omega-3 study https://pubmed.ncbi.nlm.nih.gov/28126360/
Training induced mitochondrial adaptations which may contribute to improved mitochondrial function. This mitochondrial response was modulated by DHA supplementation.
https://pubmed.ncbi.nlm.nih.gov/27698953/
Influence of fish oil supplementation and strength training on some functional aspects of immune cells in healthy elderly women. https://pubmed.ncbi.nlm.nih.gov/26059004/

Joint

Randomized placebo-controlled pilot trial of omega 3 fatty acids for prevention of aromatase inhibitor-induced musculoskeletal pain. https://pubmed.ncbi.nlm.nih.gov/29101597/
Specialised pro-resolving mediators of inflammation in inflammatory arthritis. https://pubmed.ncbi.nlm.nih.gov/27033423/
Fish oil in knee osteoarthritis: a randomised clinical trial of low dose versus high doce. https://pubmed.ncbi.nlm.nih.gov/26353789/
The Effect of Omega-3 Fatty Acids in Patients With Active Rheumatoid Arthritis Receiving DMARDs Therapy: Double-Blind Randomized Controlled Trial

Mood

Moody kids years later: Long-term outcomes of youth from the Omega-3 and therapy (OATS) studies. https://pubmed.ncbi.nlm.nih.gov/33285389/
A 52-week prophylactic randomised control trial of omega-3 polyunsaturated fatty acids in bipolar disorder . https://pubmed.ncbi.nlm.nih.gov/33340432/

Heart Disease and Stroke

Plasma Phospholipid Long-Chain ω-3 Fatty Acids and Total and Cause-Specific Mortality in Older Adults: A Cohort Study: Annals of Internal Medicine: Vol 158, No 7 (acpjournals.org)
Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association | Circulation (ahajournals.org)

Decrease of Triglycerides

544.full.pdf (bmj.com)
Effect of Eicosapentaenoic and Docosahexaenoic Acids Added to Statin Therapy on Coronary Artery Plaque in Patients With Coronary Artery Disease: A Randomized Clinical Trial - PubMed (nih.gov)

Dry Eye

N−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease | NEJM
Efficacy of Marine ω-3 Fatty Acid Supplementation vs Placebo in Reducing Incidence of Dry Eye Disease in Healthy US Adults: A Randomized Clinical Trial - PubMed (nih.gov)

Depression

The efficacy and safety of nutrient supplements in the treatment of mental disorders: a meta-review of meta-analyses of randomized controlled trials - PubMed (nih.gov)
Effect of Long-term Supplementation With Marine Omega-3 Fatty Acids vs Placebo on Risk of Depression or Clinically Relevant Depressive Symptoms and on Change in Mood Scores: A Randomized Clinical Trial | Complementary and Alternative Medicine | JAMA | JAMA Network

Anxiety, Stress

Association of Use of Omega-3 Polyunsaturated Fatty Acids With Changes in Severity of Anxiety Symptoms: A Systematic Review and Meta-analysis | Anxiety Disorders | JAMA Network Open | JAMA Network

During Pregnancy Positive Effects on Children

Seven-Year Follow-up of Children Born to Women in a Randomized Trial of Prenatal DHA Supplementation | Child Development | JAMA | JAMA Network

Early Childhood Effects on Language

Effect of Docosahexaenoic Acid Supplementation vs Placebo on Developmental Outcomes of Toddlers Born Preterm: A Randomized Clinical Trial | Cardiology | JAMA Pediatrics | JAMA Network
The Essentiality of Arachidonic Acid in Infant Development - PMC (nih.gov)

Alzheimer’s

Nutrients | Free Full-Text | Red Blood Cell DHA Is Inversely Associated with Risk of Incident Alzheimer’s Disease and All-Cause Dementia: Framingham Offspring Study (mdpi.com)

Memory Enhancement

Long-chain omega-3 fatty acids improve brain function and structure in older adults - PubMed (nih.gov)

Muscle Pain after Exercise

The effects PCSO-524®, a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus), on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: a randomized, placebo controlled trial | Journal of the International Society of Sports Nutrition | Full Text (biomedcentral.com)

Softgels Formulation:

Nutra® manufactures a variety of softgel products thanks to its Innovagel® Advanced Softgel Technology toolbox. Both from marine and plant oils these advanced technologies delivers high-end products that include sensitive oil mixtures and difficult formulations such us viscous suspensions, with up to 50% solid and hydrophilic ingredients. From simple oils to complex suspensions, our advanced Innovagel® technology processes are optimized to deliver consistent quality softgels. Our team of experts focus on uniformity and stability of complex suspensions, shell and seam strength to avoid leakers, and prevention of oxidation throughout the manufacturing process

Liquids Formulation:

In addition to the utmost purity and quality, KD Nutra® business partners are also assured of the minimal Odor, Superior Taste, which bespeaks of the high quality and purity of our oils. These attributes help our partners create products so fresh and appealing, they practically swim off the shelf. Over the last 30 years, KD Nutra® has gained valuable know-how with flavors and the effective use of antioxidants. This important competency has resulted in a wealth of stability data that allows us to effectively guide formulation and new product development projects. Our product development specialists will work closely with your team to create custom blends or bulk finished products.